前庭造型瘤（VS）通常从内耳生长到大脑。它可以分为两个区域，分别对应于内耳管内或外部。外部区域的生长是决定疾病管理的关键因素，其次是临床医生。在这项工作中，提出了将细分分为内部/优质零件的VS分割方法。我们注释了一个由227个T2 MRI实例组成的数据集，对137名患者进行了纵向获得，不包括术后实例。我们提出了一种分阶段的方法，第一阶段进行整个肿瘤分割，第二阶段使用T2 MRI以及从第一阶段获得的掩码进行了术中/极度分割。为了提高预测的肉类边界的准确性，我们引入了特定于任务的损失，我们称之为边界距离损失。与直接仪内分割任务性能（即基线）相比，评估了该性能。我们所提出的方法采用两阶段方法和边界距离损失，分别达到0.8279+-0.2050和0.7744+-0.1352，分别为室外和室内室内区域，显着提高了基线，这给出了0.7939+的骰子得分-0.2325和0.7475+-0.1346分别用于室外和室内区域。

域适应（DA）最近在医学影像社区提出了强烈的兴趣。虽然已经提出了大量DA技术进行了用于图像分割，但大多数这些技术已经在私有数据集或小公共可用数据集上验证。此外，这些数据集主要解决了单级问题。为了解决这些限制，与第24届医学图像计算和计算机辅助干预（Miccai 2021）结合第24届国际会议组织交叉模态域适应（Crossmoda）挑战。 Crossmoda是无监督跨型号DA的第一个大型和多级基准。挑战的目标是分割参与前庭施瓦新瘤（VS）的后续和治疗规划的两个关键脑结构：VS和Cochleas。目前，使用对比度增强的T1（CET1）MRI进行VS患者的诊断和监测。然而，使用诸如高分辨率T2（HRT2）MRI的非对比度序列越来越感兴趣。因此，我们创建了一个无人监督的跨模型分段基准。训练集提供注释CET1（n = 105）和未配对的非注释的HRT2（n = 105）。目的是在测试集中提供的HRT2上自动对HRT2进行单侧VS和双侧耳蜗分割（n = 137）。共有16支球队提交了评估阶段的算法。顶级履行团队达成的表现水平非常高（最佳中位数骰子 - vs：88.4％; Cochleas：85.7％）并接近完全监督（中位数骰子 - vs：92.5％;耳蜗：87.7％）。所有顶级执行方法都使用图像到图像转换方法将源域图像转换为伪目标域图像。然后使用这些生成的图像和为源图像提供的手动注释进行培训分割网络。

我们介绍$ \ texit {inextremis} $，弱监督3D方法使用特别弱的列车时间注释训练深度图像分割网络：仅在感兴趣对象的边界处只有6个重点点击。我们的全自动方法培训结束到底，不需要任何测试时间注释。从极端点，3D边界框在感兴趣的对象周围提取。然后，生成连接极端点的深层测地仪以增加边界盒内的“注释”体素的量。最后，使用来自条件随机场制剂的弱监督正则损耗来促进均匀区域的预测一致性。对前庭施瓦马瘤分段的大开放数据集进行了广泛的实验。 $ \ Textit {Inextremis} $获得竞争性能，基于边界框的其他弱监管技术完全监督和表现。此外，给定固定的注释时间预算，$ \ textit {inextremis} $胜过全面监督。我们的代码和数据在线获得。

Accurate determination of a small molecule candidate (ligand) binding pose in its target protein pocket is important for computer-aided drug discovery. Typical rigid-body docking methods ignore the pocket flexibility of protein, while the more accurate pose generation using molecular dynamics is hindered by slow protein dynamics. We develop a tiered tensor transform (3T) algorithm to rapidly generate diverse protein-ligand complex conformations for both pose and affinity estimation in drug screening, requiring neither machine learning training nor lengthy dynamics computation, while maintaining both coarse-grain-like coordinated protein dynamics and atomistic-level details of the complex pocket. The 3T conformation structures we generate are closer to experimental co-crystal structures than those generated by docking software, and more importantly achieve significantly higher accuracy in active ligand classification than traditional ensemble docking using hundreds of experimental protein conformations. 3T structure transformation is decoupled from the system physics, making future usage in other computational scientific domains possible.

Adversarial imitation learning (AIL) has become a popular alternative to supervised imitation learning that reduces the distribution shift suffered by the latter. However, AIL requires effective exploration during an online reinforcement learning phase. In this work, we show that the standard, naive approach to exploration can manifest as a suboptimal local maximum if a policy learned with AIL sufficiently matches the expert distribution without fully learning the desired task. This can be particularly catastrophic for manipulation tasks, where the difference between an expert and a non-expert state-action pair is often subtle. We present Learning from Guided Play (LfGP), a framework in which we leverage expert demonstrations of multiple exploratory, auxiliary tasks in addition to a main task. The addition of these auxiliary tasks forces the agent to explore states and actions that standard AIL may learn to ignore. Additionally, this particular formulation allows for the reusability of expert data between main tasks. Our experimental results in a challenging multitask robotic manipulation domain indicate that LfGP significantly outperforms both AIL and behaviour cloning, while also being more expert sample efficient than these baselines. To explain this performance gap, we provide further analysis of a toy problem that highlights the coupling between a local maximum and poor exploration, and also visualize the differences between the learned models from AIL and LfGP.

Many problems in machine learning involve bilevel optimization (BLO), including hyperparameter optimization, meta-learning, and dataset distillation. Bilevel problems consist of two nested sub-problems, called the outer and inner problems, respectively. In practice, often at least one of these sub-problems is overparameterized. In this case, there are many ways to choose among optima that achieve equivalent objective values. Inspired by recent studies of the implicit bias induced by optimization algorithms in single-level optimization, we investigate the implicit bias of gradient-based algorithms for bilevel optimization. We delineate two standard BLO methods -- cold-start and warm-start -- and show that the converged solution or long-run behavior depends to a large degree on these and other algorithmic choices, such as the hypergradient approximation. We also show that the inner solutions obtained by warm-start BLO can encode a surprising amount of information about the outer objective, even when the outer parameters are low-dimensional. We believe that implicit bias deserves as central a role in the study of bilevel optimization as it has attained in the study of single-level neural net optimization.

The Covid-19 pandemic induced a vast increase in adolescents diagnosed with eating disorders and hospitalized due to eating disorders. This immense growth stemmed partially from the stress of the pandemic but also from increased exposure to content that promotes eating disorders via social media, which, within the last decade, has become plagued by pro-eating disorder content. This study aimed to create a deep learning model capable of determining whether a given social media post promotes eating disorders based solely on image data. Tweets from hashtags that have been documented to promote eating disorders along with tweets from unrelated hashtags were collected. After prepossessing, these images were labeled as either pro-eating disorder or not based on which Twitter hashtag they were scraped from. Several deep-learning models were trained on the scraped dataset and were evaluated based on their accuracy, F1 score, precision, and recall. Ultimately, the vision transformer model was determined to be the most accurate, attaining an F1 score of 0.877 and an accuracy of 86.7% on the test set. The model, which was applied to unlabeled Twitter image data scraped from "#selfie", uncovered seasonal fluctuations in the relative abundance of pro-eating disorder content, which reached its peak in the summertime. These fluctuations correspond not only to the seasons, but also to stressors, such as the Covid-19 pandemic. Moreover, the Twitter image data indicated that the relative amount of pro-eating disorder content has been steadily rising over the last five years and is likely to continue increasing in the future.

We introduce a pivot for exact selective inference with randomization. Not only does our pivot lead to exact inference in Gaussian regression models, but it is also available in closed form. We reduce the problem of exact selective inference to a bivariate truncated Gaussian distribution. By doing so, we give up some power that is achieved with approximate inference in Panigrahi and Taylor (2022). Yet we always produce narrower confidence intervals than a closely related data-splitting procedure. For popular instances of Gaussian regression, this price -- in terms of power -- in exchange for exact selective inference is demonstrated in simulated experiments and in an HIV drug resistance analysis.

Using geometric landmarks like lines and planes can increase navigation accuracy and decrease map storage requirements compared to commonly-used LiDAR point cloud maps. However, landmark-based registration for applications like loop closure detection is challenging because a reliable initial guess is not available. Global landmark matching has been investigated in the literature, but these methods typically use ad hoc representations of 3D line and plane landmarks that are not invariant to large viewpoint changes, resulting in incorrect matches and high registration error. To address this issue, we adopt the affine Grassmannian manifold to represent 3D lines and planes and prove that the distance between two landmarks is invariant to rotation and translation if a shift operation is performed before applying the Grassmannian metric. This invariance property enables the use of our graph-based data association framework for identifying landmark matches that can subsequently be used for registration in the least-squares sense. Evaluated on a challenging landmark matching and registration task using publicly-available LiDAR datasets, our approach yields a 1.7x and 3.5x improvement in successful registrations compared to methods that use viewpoint-dependent centroid and "closest point" representations, respectively.

Linear partial differential equations (PDEs) are an important, widely applied class of mechanistic models, describing physical processes such as heat transfer, electromagnetism, and wave propagation. In practice, specialized numerical methods based on discretization are used to solve PDEs. They generally use an estimate of the unknown model parameters and, if available, physical measurements for initialization. Such solvers are often embedded into larger scientific models or analyses with a downstream application such that error quantification plays a key role. However, by entirely ignoring parameter and measurement uncertainty, classical PDE solvers may fail to produce consistent estimates of their inherent approximation error. In this work, we approach this problem in a principled fashion by interpreting solving linear PDEs as physics-informed Gaussian process (GP) regression. Our framework is based on a key generalization of a widely-applied theorem for conditioning GPs on a finite number of direct observations to observations made via an arbitrary bounded linear operator. Crucially, this probabilistic viewpoint allows to (1) quantify the inherent discretization error; (2) propagate uncertainty about the model parameters to the solution; and (3) condition on noisy measurements. Demonstrating the strength of this formulation, we prove that it strictly generalizes methods of weighted residuals, a central class of PDE solvers including collocation, finite volume, pseudospectral, and (generalized) Galerkin methods such as finite element and spectral methods. This class can thus be directly equipped with a structured error estimate and the capability to incorporate uncertain model parameters and observations. In summary, our results enable the seamless integration of mechanistic models as modular building blocks into probabilistic models.